xHMMER3x2
xHMMER3x2 results
Overview of Sequence Annotation
Domain(s) to sequence segment [156,292]
HMMER2 FP(H2)=FP(H3)? HMMER3
Domain name FP (FPR)? Evalue? Score? Length? Seq Range? FP (FPR)? Evalue? Score? Length? Seq Range?
PF01488_Shikimate_DH 
1 (6.1E-5) 4.4e-74 257.7 146 156,292 
1 (6.1E-5) 6e-46 155.9 145 156,291
PF03807_F420_oxidored 15 (9.2E-4) 1.6e-05 29.1 121 169,268 
5 (3.1E-4) 7.1e-08 32.9 118 172,268
PF02826_2-Hacid_dh_C 15 (9.2E-4) 0.00045 -80.4 265 127,269 5 (3.1E-4) 6.6e-09 35.1 89 160,235
PF13241_NAD_binding_7 10 (6.1E-4) 0.044 -23.4 376 164,275 - - - - - -
Domain(s) to sequence segment [7,141]
HMMER2 FP(H2)=FP(H3)? HMMER3
Domain name FP (FPR)? Evalue? Score? Length? Seq Range? FP (FPR)? Evalue? Score? Length? Seq Range?
PF05201_GlutR_N 1 (6.1E-5) 7.1e-50 177.3 379 7,141 1 (6.1E-5) 2.3e-47 162.9 379 7,141
Domain(s) to sequence segment [306,398]
HMMER2 FP(H2)=FP(H3)? HMMER3
Domain name FP (FPR)? Evalue? Score? Length? Seq Range? FP (FPR)? Evalue? Score? Length? Seq Range?
PF00745_GlutR_dimer 1 (6.1E-5) 5.7e-11 48.0 140 306,398 5 (3.1E-4) 9e-13 48.5 119 306,391
Alignments
PF01488_Shikimate_DH:
H2: [FP] 1 (6.1E-5) [E] 4.4e-74 [Score] 257.7 [Length] 146 [Range] 156,292
MODEL eLAkkifgksedLkdkkvLlIGAGEMgeLvAkHLlakWgakkvtiaNRTyeRAqeLAeefeggveiealpLdeLkeyLaeaDiviSaTgspepIitkemveralkkRkrrkplrllvDIAVPRDiepeVgeLegvylytvDDLkev HMMER2[PF01488_Shikimate_DH]
QUERY ELAERELG---SLHDKTVLVVGAGEMGKTVAKSLVDR-GVRAVLVANRTYERAVELARDL-GGE---AVRFDELVDHLARSDVVVSATAAPHPVIHVDDVREALRKRDRRSPI-LIIDIANPRDVEEGVENIEDVEVRTIDDLRVI Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[156 292]
H3: [FP] 1 (6.1E-5) [E] 6e-46 [Score] 155.9 [Length] 145 [Range] 156,291
MODEL elakkklekseslkdkkvlliGaGemaelvakhLlakwgvkkvvvaNRtlerakelaeelekgeeiealkleelkellaeaDvvisataseepilekeeveealkkrkaekplrllvDiavPRdvepevaeledvrlytvDdLkex HMMER3[PF01488_Shikimate_DH]
QUERY ELAERELG---SLHDKTVLVVGAGEMGKTVAKSLVDR-GVRAVLVANRTYERAVELARDL-GGE---AVRFDELVDHLARSDVVVSATAAPHPVIHVDDVREALRKRDRRSPI-LIIDIANPRDVEEGVENIEDVEVRTIDDLRVx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[156 291]
PF05201_GlutR_N:
H2: [FP] 1 (6.1E-5) [E] 7.1e-50 [Score] 177.3 [Length] 379 [Range] 7,141
MODEL vGlnHkTAPvdkLalyYlreveiREklafklktsheeealeeaLqerpgLksflghderfgipggaesggsegveaEadaviLSTCNRtEilcYvvssdeadgvaaleeFakelgvdddeededpeaaladaaiseqedqeafdvdskavpeldtkispkplthdeegaeealieatialdpDklltfsgsgeeeeeidieasllqnlakdeledcflqLyeklealaefkglhdgfsaenlldthsyllgilrrnleekikdyvkleelaglagiekdelepellrsylyvyegeeAvrHLFRVAsGLDSmVlGEpQILGQVKdAyengrlrlAreaGqqqhslGksatpttGpvengqLnrLFqkAfsvAKRVRtET HMMER2[PF05201_GlutR_N]
QUERY VGITHKEAE-----------VEELEKARF---ES-DEA-VRDIVES---F-------------------G---LS-GC--VLLQTCNRVEV--Y------A--------------------------------------------------------------SGARDRAEELGD------------L-------------------------------I-------------H--------------------------------DDAW------V-----K----------RGSEAVRHLFRVACGLESMMVGEQEILRQVKKAY-----DRAARLG----------T-L-DEA----LKIVFRRAINLGKRAREET Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[7 141]
H3: [FP] 1 (6.1E-5) [E] 2.3e-47 [Score] 162.9 [Length] 379 [Range] 7,141
MODEL iGinHktApvsklalyylreveiREklafklkasheeeelkealkekealksfarhdelkgiekeaeskgaegvedeadvviLSTCNRtEilvYvvsekeaddaaaleefakeleveeeeeeeapdtalsdsavseeeeqlsakldskavpeldlkieqktlssaeeaaeeellealialdidklkelaasseeeeeeeseaellleaakdelevlllqlredletlaevsglsegfssedlvdthslllnilrenleekikdavkleelaglakkdneeleeeaareylyvyegeeAvrHLfrVAsGLDSmVlGEdQILGQVKdAyeaaalelAreagqrqeklgksatpltgkvengqLnrLFqkAftvaKrVrteT HMMER3[PF05201_GlutR_N]
QUERY VGITHKEAE-----------VEELEKARF---ES-DEA-VRDIVES---F----------GLS-------------GC--VLLQTCNRVEV--Y------ASGAR--------------------------------------------------------------DRAEELGD------------L-------------------------------I--------------------------------------------------------H-----D-----DAWVKRGSEAVRHLFRVACGLESMMVGEQEILRQVKKAY-----DRAARLG----------T-L-DEA----LKIVFRRAINLGKRAREET Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[7 141]
PF00745_GlutR_dimer:
H2: [FP] 1 (6.1E-5) [E] 5.7e-11 [Score] 48.0 [Length] 140 [Range] 306,398
MODEL kAEaIIeeEveecFmeWlrslsPatqngevlvPtIraLRekaeeireeELeralSkkLadlpdgtLtnkdsgedadreeVlekltrslvNKlLHdPtvrLkeagdtdsAaeeegdgdrealeylkgetnhitalrrLFgL HMMER2[PF00745_GlutR_dimer]
QUERY KVEKLIEEELST-VEEELEKL-------KE-RRLVADVAKSLHEIKDRELERAL-RRL------------KTGD--PENVLQDFAEAYTKRLINVLTSAIMEL------------PD----EYR--R-----AACRALRR Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[306 398]
H3: [FP] 5 (3.1E-4) [E] 9e-13 [Score] 48.5 [Length] 119 [Range] 306,391
MODEL kAeaIIeeeveelFmawlkslspatqngevlvptIkalrekaeeireeeleralskklaklpekelkkkddgedakreavlealtrslvnkllhdPtvrLkeagesdeaeeeedegerexxxxxxxxxxxxxxxxxxxxx HMMER3[PF00745_GlutR_dimer]
QUERY KVEKLIEEELST-VEEELEKL-------KE-RRLVADVAKSLHEIKDRELERAL-RRL------------KTGD--PENVLQDFAEAYTKRLINVLTSAIMEL---------PDEYRRAxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[306 391]
PF03807_F420_oxidored:
H2: [FP] 15 (9.2E-4) [E] 1.6e-05 [Score] 29.1 [Length] 121 [Range] 169,268
MODEL kIGiIGGaGnmGeaLarglvaaGateilpphevvvansRnpeklaalaleelgeiLaedkggdvgatavsneeAaeRieaDvvfLAV....kpeaapdvlselgnAtAaasdllkgkivIsitng HMMER2[PF03807_F420_oxidored]
QUERY TVLVV-GAGEMGKTVAKSLVDRGV------RAVLVA-NRTYERAVELA-RDLG-------GEAVRFDE--LVDHLA--RSDVVVSATaaphPVIHVDDVREAL-----RKRDRRSPILIIDIANP Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[169 268]
H3: [FP] 5 (3.1E-4) [E] 7.1e-08 [Score] 32.9 [Length] 118 [Range] 172,268
MODEL xxxiiGGaGnmgealasgllaaGateslqpheivvansrnpekaeelaleelgeilaedkktdvkvtavdneeaaerieadvvvlav....kpedveevlselanataaakdalkgkivisilag HMMER3[PF03807_F420_oxidored]
QUERY xxxVV-GAGEMGKTVAKSLVDRGV------RAVLVA-NRTYERAVELA-RDLG-------GEAVRFDE--LVDHLA--RSDVVVSATaaphPVIHVDDVREAL-----RKRDRRSPILIIDIANP Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[172 268]
PF02826_2-Hacid_dh_C:
H2: [FP] 15 (9.2E-4) [E] 0.00045 [Score] -80.4 [Length] 265 [Range] 127,269
MODEL laLlLalaRriGpeadrqvkRWkraGrrdeeWasslGagawspkcFCYfallgraglreLsGkTvGIiGlGrIGravAkraklaFGmkkViaydryWSSDpkKKKEpeeaeeeeelGatryvdsLdeL...LaesDivslhlPYLTpeTrhlinaerlalMKpgAPlGePilINtARGglVDEdALieALksGrIaGAaLDVfeeEskyFfslakkdltnlPlpaEvvadaktrqkklhlllpLikllldvslpNtiadkVilTPHia HMMER2[PF02826_2-Hacid_dh_C]
QUERY FRRAINLGKRA--REETRI----SEG------AVSIGSAAVELA-----ERELG----SLHDKTVLVVGAGEMGKTVAKSLV-DRGVRAVLVANRT----YE----RAV-ELARDLGG-EAV-RFDELvdhLARSDVVVSATA------------------APHP--------------VIHVDDVREALRK---R-------------------------DRR--------------S---PILIIDIA--NPR------------- Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[127 269]
H3: [FP] 5 (3.1E-4) [E] 6.6e-09 [Score] 35.1 [Length] 89 [Range] 160,235
MODEL xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxllgkagleelsgktvGIiGlGrIGqavakrlkkafgmkkviaydrywssdpkkkkepeeaeeeeelgveeyvksldellaesDivslhlxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF02826_2-Hacid_dh_C]
QUERY xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxREL----GSLHDKTVLVVGAGEMGKTVAKSLV-DRGVRAVLVANRT----YE--RAVELARDLGGEAV-RFD-ELVDHLARSDVVVSATxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[160 235]
PF13241_NAD_binding_7:
H2: [FP] 10 (6.1E-4) [E] 0.044 [Score] -23.4 [Length] 376 [Range] 164,275
MODEL lfltdLegiEkrvLVVGGGeVAaCKRKarkLLeGaGPpAGkeVLtVAwNAPVavvFsPeltpnpaakelatpeleelrdlgadfDgkdkkaiLknqRaedakvktndnkqlveaglPielgeqAknvelpvqCvreaprlgieLlrLGAisvRsArenivekkknisntelENtldkryssnsnLKnisYDLEisenllEslsaDlsedqritilrrnfillikDqRnykepgDllslyeeatdklddlsgvfdnieeedeeeiqldeldpNEssgldksLflacvafPSRVmNiiNaLViaAT....dDRTpelNerTIiaeiLAklaaerakfGrgifLLVNvaDvsAadrsGdPggrelcdtenraLstgleFifPa HMMER2[PF13241_NAD_binding_7]
QUERY ----SLHD--KTVLVVGAGEMGK--TVAKSLVD-RG--V-R-A-VL--------V-ANR-----------TYERA--------------------------------------VEL-AR--------DL-------G--------G---------EA-----------------------------------------------------------VRF-----------D-EL-------------------------------VDHLA-----R----------SD----------VVVSATaaphPV--IHVDDV--REA----LR-KRD---RRS--PILIID--------IA---NPRD-----------VEEGV Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[164 275]
User sequence
>Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA
MEDLVCVGITHKEAEVEELEKARFESDEAVRDIVESFGLSGCVLLQTCNRVEVYASGARDRAEELGDLIHDDAWVKRGSE
AVRHLFRVACGLESMMVGEQEILRQVKKAYDRAARLGTLDEALKIVFRRAINLGKRAREETRISEGAVSIGSAAVELAER
ELGSLHDKTVLVVGAGEMGKTVAKSLVDRGVRAVLVANRTYERAVELARDLGGEAVRFDELVDHLARSDVVVSATAAPHP
VIHVDDVREALRKRDRRSPILIIDIANPRDVEEGVENIEDVEVRTIDDLRVIARENLERRRKEIPKVEKLIEEELSTVEE
ELEKLKERRLVADVAKSLHEIKDRELERALRRLKTGDPENVLQDFAEAYTKRLINVLTSAIMELPDEYRRAACRALRRAS
ELNG
Model
3 - xHMMER3x2 / 1000 (pfam release 29)
Reference
1) Choon-Kong Yap, Birgit Eisenhaber, Frank Eisenhaber, Wing-Cheong Wong, 2015,
xhmmer3x2: Utilizing HMMER3's speed and HMMER2's glocal alignment mode for large-scale protein domain annotation
Contact
yapck@bii.a-star.edu.sg
wongwc@bii.a-star.edu.sg
Copyrights Bioinformatics Institute A*STAR